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Frank Boschelli Selected Research

bosutinib

7/2015In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib.
7/2010Bosutinib: a review of preclinical studies in chronic myelogenous leukaemia.
5/2010Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors.
5/2010SKI-606 (Bosutinib) blocks prostate cancer invasion, growth, and metastasis in vitro and in vivo through regulation of genes involved in cancer growth and skeletal metastasis.
12/2009Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia.
6/2009Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts.
4/2009Valproic acid enhances bosutinib cytotoxicity in colon cancer cells.
5/2008SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells.
2/2007A Src/Abl kinase inhibitor, SKI-606, blocks breast cancer invasion, growth, and metastasis in vitro and in vivo.
12/2006In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells.
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Frank Boschelli Research Topics

Disease

16Neoplasms (Cancer)
07/2015 - 02/2002
4Breast Neoplasms (Breast Cancer)
07/2010 - 02/2007
3Colorectal Neoplasms (Colorectal Cancer)
11/2010 - 06/2005
3BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
05/2010 - 01/2003
2Neoplasm Metastasis (Metastasis)
05/2010 - 02/2007
1Prostatic Neoplasms (Prostate Cancer)
05/2010
1Brain Infarction
12/2009
1Infarction (Infarctions)
12/2009
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
12/2009
1Edema (Dropsy)
12/2009
1Brain Ischemia (Cerebral Ischemia)
12/2009
1Traumatic Brain Injuries (Traumatic Brain Injury)
12/2009
1Stroke (Strokes)
12/2009
1Ischemia
12/2009
1Pancreatic Neoplasms (Pancreatic Cancer)
06/2009
1Epilepsy (Aura)
04/2009
1Colonic Neoplasms (Colon Cancer)
04/2009
1Myeloid Leukemia (Leukemia, Myelocytic)
06/2008

Drug/Important Bio-Agent (IBA)

12bosutinibIBA
07/2015 - 01/2003
6Phosphotransferases (Kinase)IBA
07/2010 - 02/2002
4src-Family KinasesIBA
12/2009 - 05/2008
2Biomarkers (Surrogate Marker)IBA
08/2011 - 06/2011
2Molecular Chaperones (Chaperone, Molecular)IBA
11/2010 - 02/2008
2Mitogen-Activated Protein KinasesIBA
05/2010 - 02/2007
2Proteins (Proteins, Gene)FDA Link
06/2009 - 02/2008
2Somatomedin Receptors (Somatomedin Receptor)IBA
01/2009 - 06/2008
2Imatinib Mesylate (Gleevec)FDA Link
12/2006 - 01/2003
1Macrocyclic LactamsIBA
06/2011
1Firefly LuciferasesIBA
11/2010
1Transforming Growth Factor beta (TGF-beta)IBA
05/2010
1Bone Morphogenetic Protein 6IBA
05/2010
1Bone Morphogenetic Protein 2IBA
05/2010
1matrigelIBA
05/2010
1Focal Adhesion Protein-Tyrosine KinasesIBA
05/2010
1Fibronectins (Fibronectin)IBA
05/2010
1Cadherins (E-Cadherin)IBA
05/2010
1Interleukin-8 (Interleukin 8)IBA
05/2010
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2009
1Pharmaceutical PreparationsIBA
12/2009
14- ((2,4- dichloro- 5- methoxyphenyl)amino)- 6- methoxy- 7- (4- (4- methypiperazin- 1- yl)but- 1- ynyl)- 3- quinolinecarbonitrileIBA
12/2009
1EnzymesIBA
09/2009
1compound 17IBA
09/2009
1Histone Deacetylase InhibitorsIBA
04/2009
1Valproic Acid (Depakote)FDA LinkGeneric
04/2009
1Histone Deacetylases (Histone Deacetylase)IBA
04/2009
1Heat-Shock Proteins (Heat-Shock Protein)IBA
02/2008
1IntegrinsIBA
02/2007
1Steroid Receptors (Steroid Receptor)IBA
02/2007
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
02/2007
1tyrosine receptor (receptor, tyrosine)IBA
02/2007
1Indicators and Reagents (Reagents)IBA
06/2005
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2003

Therapy/Procedure

4Therapeutics
12/2009 - 06/2008